Evaluation of Toxicity of Pesticides Residues Evaluation of Toxicity of Pesticides Residues DEMETRA Project Logo
Demetra Tool
Demetra Project
Goals and Solutions
Development of Environmental Modules for Evaluation of Toxicity of pesticide Residues in Agriculture

DEMETRA is a project funded by the European Commission to address the ecotoxicity evaluation of pesticides in a way suitable for the Directive 91/414 on pesticides.

Under the DEMETRA project, five computer models have been developed to predict toxicity against five endpoints:

  1. Acute toxicity for Rainbow Trout (Oncorhynchus mykiss): LC50 96-hours exposure
  2. Acute toxicity for Water Flea (Daphnia Magna): LC50 48-hours exposure
  3. Acute oral toxicity for Bobwhite Quail (Colinus virginianus): LD50 14-days exposure
  4. Dietary toxicity for Bobwhite Quail (Colinus virginianus): LD50 8-days exposure
  5. Acute contact toxicity for Honey Bee (Apis melifera): LD50 48-hours of exposure.

The participants of the project are:

  • Istituto di Ricerche Farmacologiche “Mario Negri” (NEGRI) (Coordinator)
  • BioChemics Consulting SAS (BCX)
  • Central Science Laboratory (CSL)
  • Department of Computer Science and Engineering, University “Dunarea de Jos” of Galati (UGAL)
  • Politecnico di Milano (POLIMI)
  • University of Patras, HCI Group (UNIPATRAS)
  • Syngenta Crop Protection AG (SYNGENTA)
  • The Pesticides Safety Directorate (PSD)
  • Agricultural Centre BASF (BASF)
  • KnowledgeMiner Software (KMINER)
  • Technology for Growth (TFG)
  • University of Bradford, School of Informatics (UOB)

A book has been written describing in details the model basis, development, validation and novelties in the scenario of QSAR models for regulatory purposes.

Results of the DEMETRA project have been presented to regulators and industry at at the DEMETRA workshop in Como, 6 and 7 June, 2006.
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Disclaimer: This project is supported by the European Commission under the 5th Framework Programme. The contents of these pages are the sole responsibility of the publishers. These pages in no way represent the views of the Commission or its services.

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